Recent Progress in Polymer Therapeutics as Nanomedicines - Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications - page 83

Table 4.1 Polymeric backbone

Polymer
backbone

PEG HPMA

copolymer

PGA Dextran PEI

O

H
N

H OH

Monomer

O

n

HO H

n

COOH

Biodegradability X X √ √ X

Immunogenicity X X X √

Toxicity X X X X √

Maximal loading 2 n n 3n Charge matching

Clinical status Approved Phase II (PK2) Phase III,

(OPAXIO)

Approved* in vivo

Reference [15] [16, 17] [18] [13, 19, 20] [21, 22]

PEG: poly(ethylene glycol); HPMA: N-(2-hydroxypropyl)methacrylamide; PGA: poly(glutamic acid), PEI: polyethyleneimine.
*As a plasma expander.