Biomedical Engineering Reference
In-Depth Information
L ead 1
+
C2
R4
R3
R6
R2
R7
R1
C1
R2
V0
+
+
R5
L ead 2
+
R3
R4
Reference
Fig. 3.2
Instrumentation amplifier configuration
5. Input impedance: This should be sufficiently high so as to ensure that input
signal is not attenuated. Most common ECG amplifiers offer an input imped-
ance of 10 MX.
6. Electrode polarization: Different varieties of Ag-AgCl electrodes are used for
ECG acquisition. The small potential, generated at the electrode-electrolyte
interface, is known as half-cell potential. This small DC potential must be
considered since it can saturate the INA output, suppressing low-level ECG
signal itself. Association for the Advancement of Medical Instrumentation
(AAMI) specifies that ECG amplifiers must tolerate a DC component of up to
300 mV resulting in electrode-skin contact.
The popular three-OPAMP configuration is shown in Fig. 3.2 [ 13 ], which offers
a high CMRR by matched pair of resistors R 3 and R 4 . The input stage offers a gain
of (1 ? 2R 2 /R 1 ), followed by a differential amplifier with gain (R 4 /R 3 ). There is a
final stage, which offers a gain of (1 ? R 7 /R 6 ).
The third stage uses a filter with bandwidth
1
2pR 7 C 2
1
2pR 5 C 1
Df ¼
ð 3 : 3 Þ
Some more configurations of biopotential amplifier are available in [ 9 ]. An
important issue is power consumption of INA block. Some monolithic and low-
power designs include current balancing and transconductance stage amplifiers,
described in [ 14 - 17 ].
In addition to the certain desirable characteristics, specific design enhancements
are required, depending on the concerned biosignal:
1. Electrical interference reduction: This is mainly contributed by PLI, RF from
transmitters, and electrical appliances. Stray capacitances are formed between
the ECG lead wires and power lines. The displacement currents flow to ground
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