Cardiotoxicity Studies in Zebrafish - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 61

C HEN JN, H AFFTER P, O DENTHAL J, V OGELSANG E, B RAND M, VAN E EDEN FJ, F URUTANI -S EIKI M, G RANATO M,
H AMMERSCHMIDT M, H EISENBERG CP, J IANG YJ, K ANE DA, K ELSH RN, M ULLINS MC, and N USSLEIN -
V OLHARD C (1996). Mutations affecting the cardiovascular system and other internal organs in zebrafish.
Development 123: 293-302.
D E C LERCK F, V AN DE W ATER A, D'A UBIOUL J, L U HR, VAN R OSSEM K, H ERMANS A, and V AN A MMEL K (2002).
In vivomeasurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical
cardiovascular safety pharmacology of a new chemical entity. Fundam Clin Pharmacol 16(2): 125-140.
E CKARDT L, H AVERKAMP W, B ORGGREFE M, and B REITHARDT G (1998). Experimental models of torsade de
pointes. Cardiovasc Res 39(1): 178-193.
K EATING MTand S ANGUINETTI MC (2001). Molecular and cellular mechanisms of cardiac arrhythmias. Cell
104(4): 569-580.
L ANGHEINRICH U, V ACUN G, and W AGNER T (2003). Zebrafish embryos express an orthologue of HERG and
are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicol Appl
Pharmacol 193(3): 370-382.
M ILAN DJ, P ETERSON TA, R USKIN JN, P ETERSON RT, and M AC R AE CA (2003 Mar 18). Drugs that induce
repolarization abnormalities cause bradycardia in zebrafish. Circulation 107(10): 1355-1358.
M ILAN DJ, K IM AM, W INTERFIELD JR, J ONES IL, P FEUFER A, S ANNA S, A RKING DE, A MSTERDAM AH, S ABEH
KM, M ABLY JD, R OSENBAUM DS, P ETERSON RT, C HAKRAVARTI A, K €

AB S, R ODEN DM, and M AC R AE CA
(2009 Aug 18). Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as
regulators of myocardial repolarization. Circulation 120(7): 553-559.
N ERBONNE JM and K ASS RS (2005). Molecular physiology of cardiac repolarization. Physiol Rev 85(4):
1205-1253.
N EWTON -C HEH C, G UO CY, L ARSON MG, M USONE SL, S URTI A, C AMARGO AL, D RAKE JA, B ENJAMIN EJ, L EVY
D, D'A GOSTINO R.B. S R ., H IRSCHHORN JN, and O'D ONNELL CJ (2007). Common genetic variation in
KCNH2 is associated with QT interval duration: the Framingham Heart Study. Circulation 116(10):
1128-1136.
P FEUFER A, J ALILZADEH S, P ERZ S, M UELLER JC, H INTERSEER M, I LLIG T, A KYOL M, H UTH C, S CHOPFER -
W ENDELS A, K UCH B, S TEINBECK G, H OLLE R, N ABAUER M, W ICHMANN HE, M EITINGER T, and K AAB S
(2005). Common variants in myocardial ion channel genes modify the QT interval in the general
population: results from the KORA study. Circ Res 96(6): 693-701.
P HAM TV and R OSEN MR (2002). Sex, hormones, and repolarization. Cardiovasc Res 53(3): 740-751.
R ODEN DM(2000). Acquired longQT syndromes and the risk of proarrhythmia. J Cardiovasc Electrophysiol
11(8): 938-940.
R ODEN DM (2001). Pharmacogenetics and drug-induced arrhythmias. Cardiovasc Res 50(2): 224-231.
R ODEN DM (2004). Drug-induced prolongation of the QT interval. N Engl J Med 350(10): 1013-1022.
R ODEN DM and G EORGE AL J R ., (2002). The genetic basis of variability in drug responses. Nat Rev Drug
Discov 1(1): 37-44.
S ESTI F, A BBOTT GW, W EI J, M URRAY KT, S AKSENA S, S CHWARTZ PJ, P RIORI SG, R ODEN DM, G EORGE A.L. J R .,
and G OLDSTEIN SA (2000). A common polymorphism associated with antibiotic-induced cardiac
arrhythmia. Proc Natl Acad Sci USA 97(19): 10613-10618.
S PLAWSKI I, T IMOTHY KW, T ATEYAMA M, C LANCY CE, M ALHOTRA A, B EGGS AH, C APPUCCIO FP, S AGNELLA GA,
K ASS RS, and K EATING MT (2002). Variant of SCN5A sodium channel implicated in risk of cardiac
arrhythmia. Science 297(5585): 1333-1336.
V ERHEIJCK EE, VAN G INNEKEN AC, B OURIER J, and B OUMAN LN (1995). Effects of delayed rectifier current
blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res
76(4): 607-615.
W ARREN KS and F ISHMAN MC. (1998). “Physiological genomics”: mutant screens in zebrafish. Am J Physiol
275(1 Pt 2): H1-H7.
Y ANG P, K ANKI H, D ROLET B, Y ANG T, W EI J, V ISWANATHAN PC, H OHNLOSER SH, S HIMIZU W, S CHWARTZ PJ,
S TANTON M, M URRAY KT, N ORRIS K, G EORGE A.L. J R ., and R ODEN DM (2002). Allelic variants in long-QT
disease genes in patients with drug-associated torsades de pointes. Circulation 105(16): 1943-1948.
Y ANG T, S NYDERS D, and R ODEN DM (2001). Drug block of I Kr : model systems and relevance to human
arrhythmias. J Cardiovasc Pharmacol 38(5): 737-744.

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