Assessment of Drug-Induced Cardiotoxicity in Zebrafish - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 52

4.6 CONCLUSIONS
1. Drugs known to cause cardiotoxic adverse side effects in humans show similar
effects in zebrafish.
2. Zebrafish assays are rapid, reproducible, and quantitative.
3. Small amount of drug is required.
4. In vivo zebrafish cardiotoxicity assessment provides useful information
complementing data from conventional hERG assays.
REFERENCES
K IMMEL CB, B ALLARD WW, K IMMEL SR, U LLMANN B, and S CHILLING TF (1995). Stages of embryonic
development of the zebrafish. Dev Dyn 203(3): 253-310.
W ESTERFIELD M (1993). The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio rerio).
University of Oregon Press, Eugene, OR.