Assessment of Drug-Induced Cardiotoxicity in Zebrafish - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 44

Table 4.1 Summary of Zebrafish Cardiotoxicity

Concentration
(mg/mL)

Pericardial
edema

Drug name Gross morphology Circulation Thrombosis

DMSO (control) 1% 0% 0% 0% 0%

Clozapine 31 10% atrium and ventricle swollen 90% slow 40% 0%

Erythromycin 734 100% atrium and ventricle swollen 60% slow, 30% absent 100% 20% yolk, 10% pericardium

Quinidine 200 80% atrium and ventricle swollen 100% absent 30% 100% yolk, 40% ventricle

Terfenadine 20 50% atrial swelling caused

compression of ventricle

100% absent 60% 80% yolk, 10% tail

Astemizole 4.6 40% atrium and ventricle swollen 80% absent, 20% slow 100% 100% yolk

Amiodarone 8.75 20% atrium and ventricle swollen 100% absent 50% 0%

Lidocaine 117 20% atrium and ventricle swollen 20% slow 10% 0%

Verapamil 98.2 0% 0% 30% 0%

Haloperidol 5.65 80% atrium and ventricle swollen

with asynchrony between
chambers

80% slow, 20% absent 60% 50% yolk

Clomipramine 56 70% swollen ventricle 80% absent, 20% slow 70% 10% yolk