Developmental Toxicity Assessment in Zebrafish - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 23

Table 2.4 Assessment of Compound Teratogenicity in Zebrafish

Zebrafish

Zebrafish
teratogen

Mammalian
teratogen

Correct
prediction Compound LC 50 (mM) Body Heart Liver GI

Dimethyl phthalate ND No No No No None None Yes

Retinol 1146 Yes Yes Yes Yes Weak Weak Yes

Valproic acid 110.9 Yes Yes No No Weak Weak Yes

BMS -A (RAR alpha agonist 1) 4.7 Yes Yes Yes Yes Potent Potent Yes

BMS -B (RAR alpha agonist 2) 1.3 Yes Yes Yes Yes Potent Potent Yes

BMS -C (RAR beta agonist)

15 Yes Yes Yes No Potent Potent Yes

Penicillin G ND No No No No None None Yes

Isoniacide ND No No No No None None Yes

Ascorbic acid ND No No No No Can't determine None Can't determine

Diphenylhydantoin ND No No No No None Weak No

Cytosine arabinoside 1478 Yes Yes Yes Yes Potent Potent Yes

9-cis-Retinoic acid 258.4 Yes Yes Yes Yes Potent Potent Yes