Caudal Fin Regeneration in Zebrafish - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 300

Figure 22.1 Major stages of
epimorphic fin regeneration in adult
zebrafish caudal fins. A series of
cartoons depicting the longitudinal
section of a single adult fin ray during
the major stages of regeneration are
shown in (a)-(d). (a) Mature fin ray
covered by epithelium containing a
series of bony segments that protect a
mesenchymal core. (b) Following
amputation, epithelial cells (blue)
migrate laterally over the wound to
form the AEC. (c) Following formation
of the AEC and immature blastema
(not pictured), blastemal cells
segregate into the distal blastema
(purple) and highly proliferative
proximal blastema (red). (d) Following
formation of the proximal and distal
blastemas, a period of regenerative
outgrowth is characterized by intense
proliferation, cell migration,
differentiation, and patterning.
(e) Upon completion of regenerative
outgrowth and restoration of
preamputation size and form of the fin,
regenerative signaling is terminated.
(See the color version of this figure in
Color Plates section.)