Biomedical Engineering Reference
In-Depth Information
12.7.3 A Final Word on Behavioral Screening
Screening for developmental toxicity, or for any adverse health effect, necessarily
requires a compromise between the efficiency of a test method and the completeness
of the data it can provide. While there may be, perhaps, myriad avenues for future
exploitation of the behavioral preparation described in this chapter, it is impossible to
say at this time which will be most useful in identifying and prioritizing chemicals for
adverse effects on the nervous system. It is likely, however, that the current behavioral
preparation will be a valuable addition to screening studies, and, given its versatility,
in further characterizing the effects of toxicants on the developing nervous system.
ACKNOWLEDGMENTS
The authors thank Beth Padnos, Brenda Proctor, and Dr. David Kurtz for maintenance
and upkeep of the zebrafish colony. T.D. Irons is supported by the following NIH
predoctoral traineeships: the NIGMS Initiative for Maximizing Student Diversity and
the NIEHS National Research Service Award (T32 ES007126). The authors also
thank Drs. Kevin Crofton and William Mundy for reviewing earlier versions of this
manuscript.
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