Hepatotoxicity Testing in Larval Zebrafish - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 93

Table 8.1 Comparison of Compound-Induced Hepatotoxicity in Zebrafish and Mammals

Compound Zebrafish toxicity Mammalian toxicity

Hepatotoxic compounds
a-Naphthyl isocyanate Liver necrosis

Liver toxic to mammals

Amiodarone Liver necrosis,

hepatomegaly,
yolk retention

Severely liver toxic to humans

Aspirin Liver necrosis Liver toxic to mammals

Danazol Liver necrosis,

yolk retention,
intestinal toxicity

Severely liver toxic to humans
after metabolism

Furazolidone Liver necrosis,

yolk retention

Moderately liver toxic to humans

Ibuprofen Liver necrosis Liver toxic to mammals

Naproxen Liver necrosis Liver toxic to mammals

Ridogrel Liver necrosis,

yolk retention

Liver toxic to mammals

Tamoxifen Liver necrosis Moderately liver toxic to humans

after metabolism

Troglitazone Liver necrosis Liver toxic to humans

(withdrawn from market)

Valproic acid Liver necrosis Liver toxic to mammals

Wyeth 14643 Liver necrosis Liver toxic to mammals

Diasatine Non-liver toxic Liver toxic to humans

but not mammals

Ketoconazole Non-liver toxic

(but limited uptake)

Liver toxic to mammals

Sodium valproate Non-liver toxic

(but limited uptake)

Severely liver toxic to humans
after metabolism

Control compounds
Astemizole Non-liver toxic,

acutely toxic (cardiotoxic)

Non-liver toxic,
causes QT prolongation

Biotin Non-liver toxic Non-liver toxic

HP-b-CD Non-liver toxic Non-liver toxic

Haloperidol Non-liver toxic,

acutely toxic (cardiotoxic)

Non-liver toxic,
causes QT prolongation

Metformin Non-liver toxic Non-liver toxic

Paracetamol Non-liver toxic Non-liver toxic

(except at high concentration)

Saccharin Non-liver toxic Non-liver toxic

Sucrose Non-liver toxic Non-liver toxic

Gentamycin Liver necrosis, hepatomegaly Non-liver toxic; a nephrotoxin

Praziquantel Liver necrosis Non-liver toxic; an antihelminthic