In Vivo Recording of the Adult Zebrafish Electrocardiogram - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 69

compared with in vitro technologies. Nevertheless, when used in combination with a
higher throughput technique, such our previously published embryonic zebrafish
assay, this adult zebrafish model will allow direct assessment of the QT interval. The
methods described here add to the available assays for detecting drug-induced
cardiotoxicity in a model with remarkably similar heart rate and repolarization time
as humans. Recording the electrocardiogram of the adult zebrafish will permit the
cost-effective screening of QT prolonging drugs.
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