Biomedical Engineering Reference
In-Depth Information
Image-Based CFD Modeling of Cerebral
Aneurysms
Juan Cebral
Abstract Image-based computational fluid dynamics (CFD) has been increasingly
used to investigate the role of hemodynamics in the mechanisms responsible for the
development, progression and rupture of intracranial aneurysms. A key aspect of
this approach is to be able to connect hemodynamics information to clinical data
and observations and thus test hypotheses about the underlying mechanisms or to
answer specific clinical questions. This requires large numbers of models in order to
produce statistically significant results which in turn require efficient simulation
tools and methods. Likewise, this methodology is being used to investigate the
effects of different endovascular devices and procedures to improve designs and
treatment plans. Again this requires further enhancements to the simulation
methods to handle endovascular devices efficiently. This presentation will summa-
rize our efforts in the development of image-based CFD methods and their applica-
tion to the study of cerebral aneurysms. Particular attention will be paid to the
following focus areas: (1) mechanisms of aneurysm evolution, (2) analysis of
aneurysm rupture risk, and (3) effects of flow diverting devices for intracranial
aneurysms.
J. Cebral (
*
)
Center for Computational Fluid Dynamics, George Mason University,
Fairfax, VA 22030, USA
e-mail:
jcebral@gmu.edu
