Biomedical Engineering Reference
In-Depth Information
are available to provide insight into membrane protein flexibility, dynamics, and
interactions. Future applications of DNA-nanostructure-based alignment media give
this technology the ability to rise up to meet this challenge, and the application of
DNA nanostructures, as described in this chapter, will continue to have an important
impact in this NMR structure determination. DNA-nanotube developments are
capable of providing a clearer view into what has long constituted a major blind
spot in structural biology: the dynamic molecular interactions that control signaling
events occurring at the cellular membrane, as well as the mechanisms governing
cellular influx and efflux via carriers and channels across the membrane. This
presents an exciting potential for contributing new knowledge about the molecular
mechanisms of membrane proteins, determining their roles in human disease, and
paving the way for future drug design.
Acknowledgments
The author thanks James Chou (Harvard University) for helpful discussions
concerning NMR spectroscopy.
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