DNA Nanotechnology and Drug Delivery - DNA Nanotechnology: From Structure to Function - page 322

15.5 Summary

In summary, these wonderful works showed that 3D DNA nanostructures, like the
above-mentioned tubes, tetrahedrons, origami nanotube, and origami nanorobot,
have the potential to be excellent candidates for developing multifunctional-targeted
drug delivery systems.
Future works to develop DNA 3D nanostructures as drug delivery nanocarrier
systems might need to focus on the following areas:

1. Study other existing DNA 3D nanostructures' possible application for drug
delivery purpose, especially those cage-like DNA nanostructures, such as DNA
polyhedron [ 13 ] and DNA origami tetrahedron [ 21 ]. Improve the stability of the
DNA 3D nanostructures possibly by using DNA analogs like locked nucleic acids
(LNA) [ 22 ] at connection parts of those DNA 3D nanostructures.
2. Develop better strategies for the control release of drugs from the DNA 3D
nanocarriers once get into the targeted cells.
3. Taking advantages of the natural interactions between DNA and protein/nucleic
acids, incorporate specific protein/nucleic acids binding sequences [ 23 ]orsmall
drug molecules into DNA 3D nanostructures, and use the special designed DNA
3D nanostructures to mediate interested biological pathways [ 24 ].

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