Biomedical Engineering Reference
In-Depth Information
Chapter 15
DNA Nanotechnology and Drug Delivery
Wanqiu Shen
Abstract
DNA 3D nanostructures have the promising features to be the universal
nanocarriers for smart or targeted drug delivery. In this chapter, we will review
recent works on using DNA nanotube, DNA tetrahedron, DNA origami nanotube,
and DNA origami nanorobot as drug delivery nanocarriers. Their researches showed
that specially designed DNA 3D nanostructures, especially DNA tetrahedron,
demonstrated great cell uptaking efficacy and are stable for both in vitro and in vivo
drug delivery purpose. The exploratory works on DNA 3D nanocarriers assisted
the study on cytosine-phosphate-guanine (CpG)-induced immunostimulation, and
SiRNA gene silencing paved the way for DNA 3D nanostructures' real therapeutic
application.
Keywords
DNA nanotube • DNA tetrahedron • DNA origami nanotube •
DNA nanorobot • Folate • Cytosine-phosphate-guanine (CpG) • SiRNA • Gene
silencing
15.1
Introduction
The emergence of nanotechnology and the ongoing research of identifying new
disease biomarkers and associated ligands make it possible for smart or targeted
drug delivery, which is crucial for cancer treatment and gene therapy. Several
nanotechnology-based drug delivery systems, including liposome and polymer
nanoparticles, have already been approved for clinical use. However, those systems
W. Shen (
)
Department of Chemical Biology, College of Pharmacy, Tianjin Medical University,
Qixiangtai Road, Heping District, Tianjin 300070, China
e-mail:
wshen@tijmu.edu.cn
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