DNA Origami Nanostructures - DNA Nanotechnology: From Structure to Function - page 213

Fig. 10.5 DNA origami on lithographically patterned surfaces. ( a ) Placement of DNA origami
triangles onto a variety of shapes (Reprinted with permission from Macmillan Publishers Ltd: Ref.
[ 70 ], copyright 2009). ( b ) Gold nanoparticles arrays (Reprinted with permission from Macmillan
Publishers Ltd: Ref. [ 71 ], copyright 2010)
DNA tiles sample. Selectively absorption of DNA origami on patterned chemically
modified graphene is also reported [ 69 ]. The authors have systematically compared
the absorption behaviors on different graphene derivatives such as graphene oxide
(GO), reduced graphene oxide (rGO), and nitrogen-doped reduced graphene oxide
(NrGO). Among them, GO and NrGO showed high-yield adsorption and patterning
of DNA origami structures.
In contrast to the above works, Rothemund and Wallraff reported the placement
of triangular DNA origami units into holes on SiO 2 and diamond-like carbon
surface (Fig. 10.5 a) [ 70 ], which were also fabricated with EBL method. The
parameters affecting the placement, such as length, depth, and modification of
the holes; Mg 2C concentration; time for the absorption; and rinsing method, were
all extensively studied. It was found that if the size of DNA origami matches
well with the hole, the correct binding yield will be very high. Furthermore,
larger geometrically analogous hole templates, including parallelograms, hexagons,
trapezoids, and larger triangles, can be filled piecewise with size-matched DNA
origami combinational structures. Cha et al. further extended this work by uti-
lizing DNA origami as a template for gold nanoparticles (Fig. 10.5 b) [ 71 ]. This
extended work not only realized the combination of bottom-up self-assembly
with top-down EBL etching but also exhibited the great potentials in fabricating
hierarchical hybrid nanostructures which is still a big challenge for contemporary
nanoscience.