Biomedical Engineering Reference
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Fig. 10.4 Building larger structures. ( a ) Using a 26-kilobase single-strand DNA scaffold (Repro-
duced from Ref. [ 43 ] with permission of the Royal Society of Chemistry). ( b ) Double-stranded
DNA as a unified scaffold (Reprinted with the permission from Ref. [ 44 ]. Copyright 2012
American Chemical Society). ( c ) Higher-order assembly of zigzag DNA origami (Reprinted
with the permission from Ref. [ 49 ]. Copyright 2010 American Chemical Society). ( d )2D
pattern assembled from jigsaw pieces (Reprinted with the permission from Ref. [ 51 ]. Copy-
right 2011 American Chemical Society). ( e ) 2D array assembled from cross-shaped pieces
(Reproduced from Ref. [ 52 ] with permission of John Wiley & Sons Ltd.) ( f ) Superorigami
using preformed scaffold frames (Reprinted with the permission from Ref. [ 55 ]. Copyright
2011 American Chemical Society). ( g ) Higher-order assembly through programmed blunt-end
stacking interactions (Reprinted with permission from Macmillan Publishers Ltd: Ref. [ 56 ],
copyright 2011)
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