Biomedical Engineering Reference
In-Depth Information
Fig. 10.2 DNA origami nanostructures. ( a ) China map (Reprinted from Ref. [ 12 ], with kind
permission from Springer Science
Business Media). ( b ) Dolphin with a flexible tail (Reprinted
with the permission from Ref. [ 13 ]. Copyright 2008 American Chemical Society). ( c ) DNA box
with a controllable lid (Reprinted with permission from Macmillan Publishers Ltd: Ref. [ 14 ],
copyright 2009). ( d ) DNA tetrahedron container (Reprinted with the permission from Ref. [ 17 ].
Copyright 2009 American Chemical Society). ( e ) Various 3D shapes composed of honeycomb
lattice (Reprinted with permission from Macmillan Publishers Ltd: Ref. [ 18 ], copyright 2009).
( f ) 3D multilayer shapes packed on hexagonal and hybrid lattices (Reprinted with the permission
from Ref. [ 21 ]. Copyright 2009 American Chemical Society). ( g ) A 3D prepressed DNA tensegrity
structure (Reprinted with permission from Macmillan Publishers Ltd: Ref. [ 24 ], copyright 2010)
C
connected by the “hinge” strands on corresponding sheet edges. Subsequently the
entire box was formed by hinging six interconnected sheets. This box has a size of
42 36 36 nm 3 which has been confirmed by AFM, cryo-TEM, SAXS, and DLS.
Notably, the lid was functionalized with a lock-key system to control its opening
which could be read out by FRET switches. Soon after this publication, there
appeared several other 3D DNA origami objects using similar design principles.
Kuzuya and Komiyama have constructed a similar DNA origami box but without
Search WWH ::




Custom Search