Biomedical Engineering Reference
In-Depth Information
Fig. 8.7
A proximity-based DNA assembly line for creating nanoparticle superstructures
(Reprinted by permission from Macmillan Publishers Ltd: Ref. [
39
], copyright 2010)
that ligand transfer between nanoparticles might happen due to their different
thiol affinities, which could pose a potential danger to the stability of DNA-
programmable heteronanostructures. Also, the different chemical and colloidal
stabilities of different nanomaterials could bring some other problems to a self-
assembly process. Our research clearly revealed a good compatibility between the
DNA-decorated gold and platinum nanoparticles, which would allow the fabrication
of even more complicated nanostructures for functional explorations.
8.3.5
Proximity-Controlled Nanoparticle Assembly
via Integrated DNA Nanorobots
One recent work by Seeman et al. excellently demonstrated that a tensegrity
triangle-based DNA walker and three serially arranged two-state PX/JX2 switches
could happily work together on a DNA origami to make some real products
by sequentially and selectively (controlled by proximity) picking up different
gold nanoparticle parts and equipping them on the DNA walker (Fig.
8.7
)[
39
].
The researchers took advantage of state-of-the-art DNA nanotechnologies includ-
ing DNA origami and DNA nanomachinery to achieve their goals with precise
Search WWH ::
Custom Search