Biomedical Engineering Reference
In-Depth Information
Fig. 8.1
Surface-assisted asymmetrical decoration of gold nanoparticles by DNA and the assem-
bly of dimeric as well as Janus nanoparticle clusters (Reprinted by permission from Macmillan
Publishers Ltd: Ref. [
31
], copyright 2009)
8.3.1
Site (or Domain)-Specific DNA Attachment
on a Nanoparticle
Although most of the DNA-nanoparticle assemblies are formed in a homogeneous
solution, the existence of a heterogeneous surface provides some novel controls
on DNA decoration and the assembly of nanoparticles [
28
-
30
]. Maye and Gang
et al. reported a high-throughput method to fabricate discrete gold nanoparticle
clusters through a surface-confined sequential bio-recognition, immobilization,
and product release process (Fig.
8.1
)[
31
]. The method facilitated anisotropic
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