Biomedical Engineering Reference
In-Depth Information
Chapter 8
DNA-Directed Assembly of Nanophase
Materials: An Updated Review
Huiqiao Wang and Zhaoxiang Deng
Abstract
DNA nanotechnology makes use of DNA strands to build highly
engineerable supramolecular structures from the bottom-up. Such a research field
has been experiencing a fruitful development during the past decades. In materials
science, an ambitious goal is to obtain materials with designable structures and
predictable functions based on a suitable synthetic strategy. The rapid growth and
expansion of the area of DNA nanotechnology have provided a useful technological
platform suitable to demonstrate DNA's unique roles in nanomaterials science.
Although nanoparticle-based materials have been employed for controllable DNA
conjugation and DNA-programmable self-assembly, some challenges still exist.
In this chapter, we try to highlight the latest developments in DNA-directed
nanophase materials, including new strategies for DNA decoration of gold and
carbon-based nanomaterials, DNA origami-based nanoassembly templates, and
DNA-conjugated non-gold nanoparticles with specifiable bonding valences, in
response to the challenges we are currently facing.
Keywords
DNA • Nanomaterial • Assembly • Programmability • Conjugation
8.1
Introduction
Over the past three decades, DNA, the blueprint of life, has proved to be a highly
engineerable supramolecule that affords various static and dynamic nanostructures
based on programmable Watson-Crick base-pairing interactions, with a full capabil-
ity of structure and dimensionality control. In 1982, Prof. Nadrian Seeman at New
H. Wang • Z. Deng (
)
Department of Chemistry, University of Science and Technology of China, Hefei,
Anhui 230026, China
e-mail:
zhxdeng@ustc.edu.cn
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