Biomedical Engineering Reference
In-Depth Information
• Medium selectivity, i.e., respond to special compounds present in the sample.
• High stability.
• High reproducibility and reliability.
• Short response and recovery time.
• Dynamic and longlasting.
• Easy to calibrate.
• Easily processable data output.
• Small size.
Number of types of sensors are available and used as E-nose sensors for the
analysis of volatile gases, which includes metal oxide semiconductors (MOS),
conducting polymers (CP), chemocapacitors; MOS field effect transistors (MOS-
FET), quartz crystal microbalance (QCM), surface acoustic wave (SAW), and
SPR. The sensors which are used to detect the molecules of chemicals are based on
the measurement principles such as electrical, thermal, optical, and mass changes.
6.5 Biochemical Sensors
A chemical sensor is defined as a device that transforms chemical information,
ranging from the concentration of a specific sample component to total compo-
sition analysis, into an analytically useful signal. Odor molecules based on the
reaction between the odor molecules and the objective sensing materials on the
sensor surface detected by chemical biosensors. These reactions activate a positive
change in physical properties, i.e., mass, volume, or other. This change is con-
verted into an electronic signal by a transducer.
The combination of bio and electrochemistry, solid-state and surface physics,
bioengineering, data processing implies the possibility of a new generation of
highly specific, sensitive, selective, and reliable biochemical sensors.
Different types of transducers are used in chemical sensors: optical, electro-
chemical, heat-sensitive, and mass-sensitive. This transducers principles also work
as biochemical sensor as described in Table 6.2 .
Table 6.2
Principle, measurand and typical examples of biochemical sensor
Principle
Measurand
Typical sensor
Conduct metric
Resistance/conductance
Tin oxide gas sensor
Potentiometric
Voltage/e.m.f.
Ion selective FET for pH
Capacitive
Capacitance/charge
Polymeric humidity sensor
Amperometric
Current
Electrochemical cell
Calorimetric
Heat/temperature
Pellistor gas sensor
Gravimetric
Mass
Piezoelectric or SAW sensors
Optical
Path length/absorption
Infra-red detector for Methane gas
Resonant
Frequency
Surface Plasmon
Fluorescent
Intensity
Fiber optic
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