Biomedical Engineering Reference
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OH
OH
OH
O
O
O
O
O
HO
HO
O
HO
NHAc
NR
′
X
NHR
′
0.8-
x
0.2
O
O
R = sialic acid
residue
O
COONa
OHOH
OH
N
NHAc
HO
OO
OH
N
RN
N
AcHN
O
N
O
RO
NR
COONa
OH
N
N
OH
R
′
N
COONa
OH
HO
HO
O
N
O
R
′
N
NR
′
NR
′
OH
R
′
N
NaOOC
AcHN
NR
′
O
O
NHAc
HO
O
O
NaOOC
O
HO
OH
HO
O
HO
OH
NaOOC
O
NaOOC
O
OH
NaOOC
OH
HO
AcHN
O
O
NHAc
HO
HO
OH
OH
HO
HO
OH
HO
NHAc
HO
HO
NHAc
HO
Figure 2.43
Chemical structure of chitosan-sialodendrimer hybrid.
OHC
NH
2
Method A
NaCNBH
3
Chitosan
<Backbone polymer>
H
2
N
NH
2
H
2
N
CO
2
Me
NH
2
Method B
Aminolysis
CONH
N
-methoxycarbonyl-
ethylchitosan
Figure 2.44
Synthetic strategy on chitosan-dendrimer hybrid.
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