Formation of Chitosan-Based Hydrogels Network - Chitosan Based Hydrogels: Functions and Applications - page 176

4
Formation of Chitosan-Based Hydrogels Network
Yuji Yin and Junjie Li
CoNTENTS
4.1 Complex Tissue from Simple Molecules ........................................................................ 180
4.1.1 ECM Component Cross-linking .......................................................................... 180
4.1.2 Performance of Cross-linking Network ............................................................. 180
4.2 Chitosan-Based Network.................................................................................................. 183
4.2.1 Complex Cross-Linking Network ....................................................................... 183
4.2.1.1 Chitosan-Gelatin PECs .......................................................................... 185
4.2.1.2 Chitosan-Alginate PECs ........................................................................ 185
4.2.1.3 Chitosan/HA PECs................................................................................. 186
4.2.1.4 Chitosan/Heparin PECs ........................................................................ 187
4.2.1.5 Chitosan-DNA PECs .............................................................................. 188
4.2.2 Ionic Cross-Linking Network .............................................................................. 188
4.2.3 Covalent Cross-Linking Network ....................................................................... 190
4.2.3.1 Dialdehyde-Cross-Linked CS................................................................ 192
4.2.3.2 Genipin-Cross-linked Chitosan............................................................ 192
4.2.3.3 Diisocyanate-Cross-Linked Chitosan.................................................. 195
4.2.3.4 Diepoxide-Cross-Linked Chitosan....................................................... 196
4.3 Multiple Component Network......................................................................................... 197
4.3.1 Hybrid Cross-linking Network ........................................................................... 197
4.3.1.1 Chitosan/Protein Cross-Linking Network ......................................... 197
4.3.1.2 Chitosan/GAG Cross-Linking Network ............................................. 199
4.3.2 Interpenetrating Network .................................................................................... 203
4.3.2.1 Semi-IPNs................................................................................................. 203
4.3.2.2 Full-IPNs................................................................................................... 206
4.4 Composite Network........................................................................................................... 207
4.4.1 Blending Composites............................................................................................. 207
4.4.1.1 Chitosan/β-TCP Composite System ..................................................... 207
4.4.1.2 Chitosan/HAp Composite System ....................................................... 208
4.4.2 Mineralization Composites .................................................................................. 209
4.4.2.1 Mineralization through Coprecipitation ............................................. 209
4.4.2.2 Mineralization through Surface Coating ............................................ 210
4.5 Self-Assembly Network .................................................................................................... 211
4.5.1 Self-Assembly Nanoparticles ............................................................................... 211
4.5.2 Self-Assembly Multilayer...................................................................................... 215
4.5.2.1 Chitosan/Protein Self-Assembly .......................................................... 215
4.5.2.2 Chitosan/Polysaccharide Self-Assembly............................................. 216
References..................................................................................................................................... 221
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