Biomedical Applications of Emission Tomography - Correction Techniques in Emission Tomography - page 26

FIGURE 2.8: Imaging-guided gene therapy paradigm of experimental
gliomas. Response to gene therapy correlates to therapeutic gene expression.
The intensity of therapeutic gene expression (cdIREStk39gfp), which is equiv-
alent to transduction eciency and the \tissue-dose" of vector-mediated ther-
apeutic gene expression, is measured by [ 18 F]FHBG-PET (in %ID/g), and the
induced therapeutic effect is measured by [ 18 F]FLT-PET (R=0.73, p<0.01).
The therapeutic effect ([ 18 F]FLT) was calculated as the difference between
[ 18 F]FLT accumulation before and after therapy.

anti-proliferative gene therapeutic effects [21]. The same imaging paradigms
that are being used to image transduced genes by PET or optical imaging can
be applied to study stem cell transplantation [28] or transcriptional regulation
in gliomas [13].

References
[1] E. O. Aboagye. The future of imaging: developing the tools for monitoring
response to therapy in oncology: the 2009 Sir James MacKenzie Davidson
Memorial Lecture. The British Journal of Radiology, 83(994):814{822,

2010.

[2] G. Antoni and B. Langstrom. Radiopharmaceuticals: molecular imaging
using positron emission tomography. Handbook of Experimental Pharma-
cology, (185 Pt 1):177{201, 2008.