Biomedical Engineering Reference
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Fig. 3 Imaging of gap junctions and hemichannels. Top right panel (six images) shows gap junc-
tional plaques, imaged at cytoplasmic face and, after force dissection, extracellular face, with
molecular resolution. Top left shows schematic and (four images) reconstituted hemichannels from
bilayer to a single open and closed channel. Bottom half shows phase images (A-D) and energy
maps ( bottom left ) of hemichannels in open and closed states. Bottom right section shows differ-
ence in interfacial energy of open and closed channels and a model pointing toward the role of
hydrophobic interactions. For details, see John et al. ( 1997 ) and Thimm et al. ( 2005 )
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