Biomedical Engineering Reference
In-Depth Information
Fig. 6
Sustained spiking evoked by CNT stimulation. Current-clamp recording from a cultured hip-
pocampal neuron reveals sustained action potential discharges evoked by DC electrical stimuli deliv-
ered by applying an electric fi eld via unchlorinated Ag electrode and conducting grease on the CNT
substrate mesh. The electrode was isolated from the extracellular solution, where neurons were main-
tained during recordings so that stimulation occurs through the CNT substrate only. © 2007 Society
for Neuroscience, modifi ed and reproduced with permission from Mazzatenta et al. (
2007
)
Fig. 7
Equivalent circuit of a multicompartmental conductance-based model neuron. Complex
2D morphologies of cultured hippocampal neurons (
a
) can be reduced into 1D nonlinear cable
structures and compartmentalized by the standard Hodgkin-Huxley approach (
b-c
).
C
m
membrane
capacitance,
E
Na
Na
+
reversal potential,
E
K
K
+
reversal potential,
E
L
leak reversal potential,
g
Na
Na
+
conductance,
g
K
K
+
conductance,
g
L
leak conductance,
R
a
axial cytoplasmic resistance,
V
m
, mem-
brane potential
