Biomedical Engineering Reference
In-Depth Information
proposed for the modeling of chemical plants to the main nanomaterial
pathways. For impact assessment, it involves the use of physiologically
based pharmacokinetic models to interpolate results on well-studied
nanoparticles to different sizes and surface transformations.
• Screening factors need to be accompanied by uncertainty estimates,
at least for the main multiplicative factors determining both the
inventory emissions and the characterization factor. The inventories
and impact characterization factors calculated for nanoproducts and
nanoemissions must therefore be used in a way that reflects the large
variation of 10 orders of magnitude between chemical characteriza-
tion factors as well as the 3 orders of magnitude uncertainty on the
individual factors. It basically enables at this stage to screen whether
direct impacts of nanoparticles are negligible, comparable, or larger
than indirect impacts linked to, for example, fine particulate emis-
sions linked to energy production.
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