Biomedical Engineering Reference
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as a function of particulate matter particle size distribution. The modeling
used to characterize uptake fraction considers the influence of source-specific
particle size distributions, coagulation, differential dry and wet removal
mechanisms, population density patterns, and differential deposition in the
respiratory tract. Deposition in different zones of the respiratory tract are also
defined as a function of particle sizes (Figure 11.11a and b).
(a)
Total respiratory tract
Nasopharyngeal
Tracheobronchial
Alveolar
1
0.9
0.8
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0
0.001
0.01
0.1
1
10
Particle diameter dp (μm)
(b)
Uptake fraction m
2
/m
2
1.E-06
1.E-06
8.E-07
6.E-07
4.E-07
2.E-07
0.E+00
0.001
0.01
0.1
1
10
Diameter dp of the particle that deposits in the respiratory
tract (µm)
FIGURE 11.11
(a) Three zone-specific and total deposition curves in respiratory tract as function of particu-
late sizes. (Based on Yeh, H.C. et al.,
Aerosol Sci. Technol.
, 25, 134, 1996.) (b)
Overall uptake
fraction accounting for particulate coagulations as determined on surface area basis. (From
Humbert, S. Geographically differentiated life-cycle impact assessment of human health. PhD
Dissertation. AAT 3402614,
20 09.)
