Biomedical Engineering Reference
In-Depth Information
TABLE 4.3 Mortality from Single Inhalation Exposure to Methanol in
Various Animal Species
Length of
Exposure
Species
LC 50 ppm
Comments
References
Rat
1 h
145,000
Head only
DuPont (unknown)
Rat
4 h
64,000
RTECS (1994)
Rat
4 h
73,000
Smith and Taylor
(1982)
Rat
4 h
98,600
Runny eyes and
nose, labored
breathing,
staggering,
apathy, and
narcosis
BASF (1980)
Rat
6 h
67,300
BASF (1980)
Rat
8 h
64,000
Saturated vapors
Smyth (2001)
Rat
8 h
>
22,500
Lington and Bevan
(1994)
Mouse
6 h
41,000
Scott et al. (1979)
Mouse
6 h
>
40,000
Lington and Bevan
(1994)
Mouse
30,600-152,800
Mashbitz et al.
(1936)
Mouse
134min
61,100
Von Burg (1994)
Mouse
6 h
41,000
NEDO (1997)
Cat
45 h
65,700
Von Burg (1994)
Cat
6 h
23,600
Von Burg (1994)
Cat
20,000-36,900
Witte (1931)
Monkey 1-18 h
10,000-40,000 Mortality
McCord (1931)
In a very early methanol inhalation studies in rhesus monkeys
indicated that lethal concentrations (percentage mortality not reported)
at
40,000 ppm) (after 1-4 hours).
Blindness associated with optic atrophy was reported, but eventual
recovery was observed (McCord, 1931). The age of this study, the lack
10,000 ppm (after 18 hours) and
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