Biomedical Engineering Reference
In-Depth Information
female/male methanol only group, respectively. The level of methanol
in the low methanol only group was 22.6/24.6mg (female/male,
respectively). Survival of both male and female in the MDA top
dose was significantly lower than the corresponding methanol control
groups. There was a difference in body weight between the top two
MDA dose groups and the corresponding methanol controls. There were
no differences in body weight between low dose MDA groups and
corresponding methanol control.
The top female MDA group and the mid dose males had lower lung
tumors incidence than the corresponding methanol control. The inci-
dence of blood vessel tumor was not affected by treatment. In the top
two dose methanol control groups there was a significantly larger
number of malignant lymphomas than in the corresponding MA groups.
Table 8.8 gives a summary of malignant lymphomas in female mice and
methanol dose in each of the six groups. The lymphoma historical
control rate was 18% at Eppley, but was reported to vary from study to
study. It should be noted that no water only control group was included
in this experiment. It is interesting to note that in the female mice
receiving just methanol, a dose-related increase in malignant lympho-
mas was noted (Table 8.8), but no trend was seen in the male mice
receiving methanol only (Table 8.9). Also of interest is that an inverse
dose relationship increase in malignant lymphomas was noted in both
TABLE 8.8 Lymphomas Versus Methanol Concentration (Female Mice)
Average Daily
Methanol
Dose, mg
a
Average
Methanol,
mg/kg bw
b
Percentage
Lymphomas
Treatment Group
0.899% methanol
84.5
2,400
40
0.444% methanol
40.8
1,160
36
0.222% methanol
22.6
645
16
0.5% MDA
41.8
1,190
4
0.25% MDA
26.2
750
28
0.125% MDA
15.3
440
36
Historical control
0
0
18
a
Average daily methanol dose based on drinking water consumption.
b
Calculated based on an average weight of 35 g.
