Biomedical Engineering Reference
In-Depth Information
both the aCat mice and their WT C3H controls were relatively
resistant to MeOH teratogenicity, the first strain of mouse to be
reported as such, precluding an evaluation of the effect of catalase
deficiency upon MeOH teratogenesis. The resistance of the aCat and
C3H WT controls could not be explained by pharmacokinetic deter-
minants since the pharmacokinetic profiles for MeOH and FA in the
aCat, hCat, and WT mice were similar, with only the hCat mice
FIGURE 7.25 Effect of MeOH on embryopathies in mice with a genetic
modulation of catalase in vivo. Pregnant dams were treated on gestational day
(GD) 8 with two doses of 2 g/kg MeOH i.p. or its saline vehicle at 4-hour
intervals, and assessed on GD 19. Each symbol represents one litter, with
the number of litters shown in parentheses, and the mean by a horizontal bar.
The symbol
indicates a difference from the respective saline treatment
(p
<
0.01 for ophthalmic anomalies and p
<
0.05 for cleft palate anomalies).
Source: From Siu et al. (2013).
