Biomedical Engineering Reference
In-Depth Information
model predicts humans to be much less sensitive than mice, by a nearly
fivefold factor (153.9mg/l vs 33.1mg/l) at 1000 ppm, and by a nearly
22-fold factor (4681.2mg/l vs 217.3mg/l) at 5000 ppm. At airborne
methanol concentrations of 250 ppm or less, however, human and
mouse blood methanol levels are very similar when both are continu-
ously exposed.
Finally, Table 6.3 and Figure 6.4 provide a direct comparison
between human steady-state blood concentrations predicted with the
modified Battelle (2006) model and the Bouchard et al. (2001) model.
The agreement between these two sets of model predictions is striking,
with differences no larger than 6% over a wide 1000-fold airborne
concentration range. It
is only at
the very highest concentrations
<
(
1000 ppm) that the saturable kinetics of the modified Battelle
(2006) model leads to noticeable differences from the straight-line
Steady-state human: Modified Battelle (2006) vs Bouchard (2001)
1000
Modified Battelle
100
Bouchard
10
1
Modified Battelle/Bouchard ratio
0.1
0.01
1
10
100
1000
10,000
Air (ppm)
FIGURE 6.4 Modified Battelle (2006) and Bouchard et al. (2001) model-
predicted steady-state human blood concentrations during continuous (steady-
state) exposure to various airborne methanol concentrations. Also depicted is
the ratio of these two predicted concentrations.