Biomedical Engineering Reference
In-Depth Information
TABLE 6.3 Human Blood Methanol Concentrations (mg/l) Predicted
by the Modified Battelle (2006) and Bouchard et al. (2001) Models at
Steady State for Various Airborne Methanol Concentrations (ppm)
Methanol in
Air, ppm
Modified Battelle
Human, mg/l
Bouchard
Human, mg/l
Ratio: ModBat H /
Bou H
1
0.0313
0.0313
1.000000
10
0.313
0.313
1.000639
50
1.569
1.565
1.00281
100
3.147
3.130
1.00550
250
7.932
7.825
1.0137
500
16.08
15.65
1.0276
525
16.9
16.43
1.0291
550
17.7
17.22
1.0304
575
18.6
18.00
1.0319
600
19.4
18.78
1.0333
625
20.2
19.56
1.0346
675
21.9
21.13
1.0375
750
24.5
23.49
1.0420
875
28.7
27.39
1.0494
1,000
33.1
31.30
1.0569
2,000
70.2
62.60
1.1209
5,000
217.3
156.5
1.3883
10,000
697.5
313.0
2.2284
Also shown is the ratio of modified Battelle (2006) model-predicted to Bouchard et al.
(2001) model-predicted blood methanol concentrations (ModBat H / Bou H). See also
Figure 6.4
1000 ppm, the original Battelle model predicted a human blood metha-
nol concentration of 521mg/l, while the modified model predicts only
33mg/l, nearly fivefold lower.
It is also important to note that the implications of the modified
Battelle model regarding human sensitivity to the toxic effects of
methanol exposure relative to that observed in mice are completely
opposite to those of the original Battelle model. Rather than predicting
humans to be more sensitive than mice, and especially so near to the
Rogers et al. (1993) NOEL dose of 1000 ppm, the modified Battelle
