Biomedical Engineering Reference
In-Depth Information
of 5000 ppm and below. Substantial nonlinearity only sets in at levels
approaching 10,000 ppm.
This is evident in Table 6.2, and also in Figure 6.3, where the steady-
state Battelle (2006) model-predicted mouse and (modified) human
blood concentrations are plotted versus airborne methanol concentra-
tion for direct comparison with the unmodified Battelle human model
predictions presented previously in Table 6.2 and Figure 6.1. At
10,000 ppm, the unmodified Battelle (2006) model predicted a human
blood methanol concentration of 12,110mg/l, while the modified
Battelle model predicts only 697mg/l, over 38-fold lower. At
Battelle (2006): Modified human vs mouse at steady-state
100,000
10,000
Mouse
1000
100
Modified
human
10
1
0.1
Modified human/mouse ratio
0.01
1
10
100
1000
10,000
Air (ppm)
FIGURE 6.3 Battelle (2006) model-predicted mouse and human steady-
state venous blood methanol concentrations versus airborne methanol con-
centration for continuous inhalation exposure. Also depicted is the ratio of
predicted steady-state human and mouse blood concentrations. The human
Battelle (2006) model was modified by (1) replacement of the human K m
estimate of 12mg/l used by Battelle with the average value of 460mg/l for
humans and monkeys reported by Perkins et al. (1995) and (2) adjustment of
the corresponding human V max to give the same low-dose slope for the blood
methanol (CVB) versus airborne concentration (CCh) relationship as that of
the Bouchard et al. (2001) model at steady state.
 
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