Exploring Differences Between PBPK Models of Methanol Disposition in Mice and Humans: Important Lessons Learned - The Toxicology of Methanol - page 153

concentration at every instant although the proportionality constant is
time dependent until steady state is reached. Starr and Festa (2003)
solved the Bouchard et al. (2001) human methanol model equations at
steady state and determined that the relationship between airborne
(C Air , in ppm) and incremental blood (C max , in mg/l) methanol concen-
trations at steady state was as follows:

¼ : :

C max 0 0313 C Air

Table 6.2 also presents the steady-state human blood methanol
concentrations predicted by the Bouchard et al. (2001) model for
comparison with those predicted by the Battelle (2006) model.
This comparison is also depicted graphically in Figure 6.2. While the
Battelle (2006) and Bouchard et al. (2001) predictions of human blood
methanol concentrations are in good agreement for airborne methanol

Steady-state human: Battelle (2006) vs Bouchard (2001)

100,000

10,000

Battelle

1000

Bouchard

100

10

1

Battelle/Bouchard ratio

0.1

0.01

1 10 100 1000 10,000

Air (ppm)

FIGURE 6.2 Battelle (2006) and Bouchard et al. (2001) model-predicted
steady-state human blood concentrations during continuous (steady-state)
exposure to various airborne methanol concentrations. Also depicted is the
ratio of these two predicted concentrations.