General Animal and Aquatic Toxicity - The Toxicology of Methanol - page 96

4.7 REPEAT EXPOSURE—DERMAL

4.7.1 Mice

There are two dermal studies (Forbes et al., 1979; Apaja, 1980) that use
methanol as a solvent/control. These studies are designed to assess
carcinogenicity of other chemicals, but also could potentially give infor-
mation on the effects of repeat dermal exposure of methanol in the
solvent/controls.No toxic effects due tomethanol treatmentwere reported.
These studies are discussed inmore detail inChapter 8 on carcinogenicity.

4.8 AQUATIC TOXICITY

The acute toxicity to fish is listed in Table 4.4. Both static and flow
through testing were used in more than a dozen fish species. In general,
the results were similar with low acute toxicity being the general pattern
of toxicity in fish.
The acute toxicity to aquatic invertebrate is in Table 4.5. In general, the
resultsweresimilar (lowacutetoxicity), inthedozenormorespecies tested.

TABLE 4.4 Acute Aquatic Methanol Toxicity to Fish

Exposure
Time
Hours Species Concentration, mg/l Comments References

Bleak 96 LC 50 ¼ 28,000 Static Bengtsson et al. (1984)

Goldfish 48 LC 50 ¼ 1,700 AQUIRE (1995)

Carp 48 LC 50 ¼ 28,000 AQUIRE (1995)

Carp 96 LC 50 ¼ 36,000 Dobson et al. (1993)

Armed
bullhead

96 LC 50 ¼ 7,900-26,070 Static Portmann and Wilson

(1971)

Bluegill 24

48
72
96

LC 50 ¼ 19,230
LC 50 ¼ 19,230
LC 50 ¼ 17.720
LC 50 ¼ 15,400

Call et al. (1983)

Bluegill 24

48
96

LC 50 ¼ 19,100
LC 50 ¼ 19,100
LC 50 ¼ 15,400

Poirier et al. (1986)