Chemistry Reference
In-Depth Information
NH
2
Cl
+
Cl
NH
2
H
2
N
NH
2
H
2
N
NH
2
Ravelling
D i rect
Sy nthesis
NH
2
NH
2
NH
2
NH
2
NH
2
Possible
complex
NH
2
O
O
N
O
O
Fig. 12 Representation of the synthetic pathway to a trefoil knot by hydrogen bond-mediated
weaving
molecules can be beautifully simple. Hope for this kind of situation might be
founded when one thinks of the NMR spectra of folded peptide structures in natural
systems, which are often very well defined because of the strongly held secondary
and tertiary structures. Certainly, the knots based on copper template chemistry
