Biomedical Engineering Reference
In-Depth Information
CHAPTER
7
Compartmental Modeling
John D. Enderle, PhD
OUTLINE
7.1 Introduction
360
7.5 One-Compartment Modeling
381
7.2 Solutes, Compartments, and
Volumes
7.6 Two-Compartment Modeling
391
360
7.7 Three-Compartment Modeling
403
7.3 Transfer of Substances between
Two Compartments Separated by
a Membrane
7.8 Multicompartment Modeling
418
362
7.9 Exercises
430
7.4 Compartmental Modeling Basics
379
Suggested Reading and References
445
AT THE CONCLUSION OF THIS CHAPTER, STUDENTS WILL BE
ABLE TO:
Explain the concept of a compartment.
Quantitatively describe the transfer of
substances separated by a membrane.
Describe how osmosis affects cell volume.
Analyze a physiological system using a
one-compartment model.
Describe and calculate the half-life of a
substance in a one-compartment model.
Use the washout curve to estimate
parameters.
Describe a pharmacokinetic model and
its use.
Describe how to maintain the concentration
of a drug in the body by repeat dosages.
Use a two-compartment model with sources
and sinks.
Use a three-compartment model with
sources and sinks in a general, mammillary,
and unilateral configuration.
Use a multicompartment model with
sources and sinks in a general, mammillary,
unilateral, and catenary configuration.
