Chemistry Reference
In-Depth Information
HO
O
O
O
O
O
O
O
OH
H
OH
O
O
O
OH
O
O
O
FIGURE 10.15
Structure of a bryostatin from marine sources.
SUMMARY
This chapter provides various important natural product contributors to human
health: the terpene-related monacolin compounds and the steroids, including corti-
sone and progesterone. Various natural product examples from terrestrial, microbial,
and marine sources are provided: the antimalarial quinine and artemisinin; and the
anticancer compounds paclitaxel and bryostatin.
QUESTIONS
1. Artemisinin is a complex oxygenated terpene. Describe the types of oxygen
bonds in the molecule.
2. What is the best approach to determine the dioxygen bridge structure in the
artemisinin molecule?
FURTHER READING
m
onaColinS
A. W. Alberts, J. Chen, G. Kuron, V. Hunt, J. Huff et al. 1980. Mevinolin: A highly potent
competitive inhibitor of hydroxymethlglutaryl-coenzyme A reductase and a cholesterol-
lowering agent.
Proc Natl Acad Sci USA
77(7):3957-3961
P. Bobek, O. Ozdín, and M. Mikus. 1995. Dietary oyster mushroom (
Pleurotus ostreatus
)
accelerates plasma cholesterol turnover in hypercholesterolaemic rat.
Physiol Res
44(5):287-291.
A. Endo, M. Kuroda, and Y. Tsujita. 1976. ML-236A, ML-236B, and ML-236C, new
inhibitors of cholesterogenesis produced by
Penicillium citrinium
.
J of Antibiotics
29(12):1346-1348.
Y. L. Lin, T. H. Wang, M. H. Lee, and N. W. Su. 2008. Biologically active components and
nutraceuticals in the Monascus-fermented rice: A review
. Applied Microbiology and
Biotechnology
77(5):965-973.
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