Biomedical Engineering Reference
In-Depth Information
Derivatives
Name
Chemical Structure
Application
Maleimide
derivative of
PEG
PEG-methyl maleimide
Thiol-specific pegylation of
antibodies, viruses, P/P
Aldehyde
derivatives of
PEG
N terminal-specific pegylation
of proteins
PEG-butylaldehyde
mPEG-amide-butylaldehyde
mPEG-urethane-butylaldehyde
PEG-pentaldehyde
PEG-amide-propionaldehyde
PEG-urethane-propioaldehyde
Multi-arm PEG
6-arm PEG
More reactive component in
hydrogel formulation
Multi-arm (PEG)
12
[(methyl-PEG
12
)
3
-
PEG
4
NHS ester]
Attach branched methyl-capped
PEG moieties to amine
groups, increase solubility
and stability, and reduce
immunogenicity of P/P drugs
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