Parenteral Delivery of Peptides and Proteins - Challenges in Delivery of Therapeutic Genomics and Proteomics - page 572

Table 11.12 Pulsatile Delivery Systems Developed for P/P Drugs

P/P Drugs Characteristics of the Delivery System Reference

BSA Biocompatible magnetic nanocomposite. Strong

interaction between the surface of the maghemite
nanoparticle and the hosting template has been
observed. Release of BSA from EVA matrices
was enhanced about 30-fold when exposed to a
magnetic field

[367,368,372]

Insulin Insulin incorporated in crosslinked poly( N -acrylolyl

pyrrolidine) polymer followed pulsatile release
due to thermosensitive properties of polymers

[373]

Horseradish
peroxidase,
albumin

Pulse release has been achieved using enzymatically
activated microencapsulated liposomes

[374]

Parathyroid hormone
closed loop system

Pulsatile release from cylindrical implant made
up of polylactic acid and three-component
polyanhydrides composed of sebacic acid, 1,3-
bis( p -carboxyphenoxy) propane and PEG were
synthesized and used as isolation layers. Implant was
prepared using the reverse solid free-form fabrication
technique. Release characterized by surface erosion

[375]

Insulin pH responsive polymeric hydrogel enclosed

immobilized glucose oxidase

[376]

Insulin Dextran methacrylate and concanavalin A

methacrylamide photopolymerized in the
presence of photoinitiator Irgacure ® to form
glucose sensitive hydrogel showed gel-sol phase
transformation in presence of glucose; used as
self-regulated insulin device

[377]

Insulin Gold nanoshell was embedded in NIPAAm- co -

acrylamide hydrogels, which absorb light in near
infrared and release insulin and other proteins in
pulsatile manner

[378]

BSA Copolymers of (2-dimethylamino) ethyl methacrylate

(DMAEMA) and 3-acrylamidephenylboronic acid
(AAPBA) show triple responsive hydrogel that is
sensitive to pH, temperature, and glucose level

[376]

into a catheter, which is inserted into a vein or artery. The pump is placed under the skin by
a surgery and can be refilled by a direct percutaneous injection into a self-sealing septum at
the top of the pump [379,380] .
2. In the direct drive system, the drive is directly transmitted to the cylindrical plunger of a
syringe by means of a roller. Examples of syringe-driven infusion devices are Autosyringe,
Penpump, Microjet, and Pharmajet [382] .
3. A pump based on peristaltic moment is a compact device generally consisting of a roller
peristaltic, a disposable bag, and a silicone outlet tube stretched around a roller mechanism.
As the roller turns, the contents of the tube are expelled from the cannula. When filling