Biomedical Engineering Reference
In-Depth Information
Table 11.8 Reported P/P Encapsulated in SLNs as Therapeutic Agent or Targeting Moiety
Along with their Techniques of Manufacturing
S. No.
Peptide/Protein
Encapsulated
Characteristics of the System
Reference
1.
D-Trp6, LHRH,
thymopentin
Water-oil-water microemulsion-based
technique, low encapsulation efficiency of
2-5%
[281,289]
   2.
Insulin,
thymocartin,
somatostatin
SLN prepared by solvent emulsification-
evaporation method, high encapsulation
efficiency
[290,291]
   3.
BSA
BSA crystals were coated using supercritical
fluid technology either with tripalmitin
or Gelucire ® , and the latter resulted in
prolonged release lipid microcapsules (80%
of intact BSA in 24 h)
[292]
   4.
BSA
Hot high-pressure homogenization and
microemulsion technique. Association
efficiency ~100
[293]
   5.
Calcitonin
Water-oil-water double emulsion. Association
efficiency 75-90%
[287]
   6.
Cyclosporin A
Microemulsion technique. Hot high-pressure
homogenization technique. Association
efficiency 6-13%, prolonged drug release
[294]
   7.
Gonadorelin
Solvent diffusion. Association efficiency
50-69%
[295]
   8.
Human
recombinant
epidermal
growth factor
Microemulsion technique; effective in vivo
targeting
[296]
   9.
Insulin
Supercritical fluid technology—association
efficiency 75%, water-oil-water double
emulsion—association efficiency 35-45%
[292,290]
10.
Streptavidin
Microemulsion technique—association
efficiency ~100
[296]
11.
Lysozyme
Cold high-pressure homogenization
technique—association efficiency ~100
[297]
12.
TAT peptide
Hot high-pressure homogenization technique.
Effective intracellular targeting
[298]
13.
Leuprolide
By combining hydrophobic ion pairing and
Oil-Oil emulsion evaporation. Increased
entrapment efficiency 74%
[286]
through entanglements, ionic forces, or hydrophobic interactions. Biodegradable
hydrogels may be prepared using synthetic or natural polymers. Hydrogels may bio-
degrade due to the presence of degradable polymer backbones, degradable crosslinks,
or pendant chains that can be cleaved from the polymer backbone. Water-soluble
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