Biomedical Engineering Reference
In-Depth Information
Disease
Condition/
Application
Protein/
Peptide
Polymers and Other Characteristics
Product Name and
Marketing Company
Lupron Depot ® (Takeda-
Abott),Eligard ®
(Sanofi-Synthelabo)
Prostate cancer
Leuprolide
acetate
11.25 mg is available in a prefilled dual-chamber syringe containing sterile
lyophilized PLGA microspheres, which, when mixed with diluent, become a
suspension intended to be given as an intramuscular injection for 3 month
Zoladex ® 10.8 mg implant designed for subcutaneous implantation with continuous
release over a 12-week period. Goserelin acetate is dispersed in a matrix of D,L-
lactic and glycolic acids copolymer
Zoladex ® (Astra
Zeneca)
Goserelin
acetate
Suprecur ® MP
(Aventis),Profect ®
Depot (Aventis)
Buserelin
acetate
Buserelin acetate 3.6 mg, 1 month depot (subcutaneous) microspheres preparation
using PLGA, used for endometriosis
Triptorelin
pamoate
Triptorelin pamoate 3.75 mg, 1-month depot preparation using PLGA microspheres,
used for prostate cancer
Trelstar™ Depot
(Pfizer)
Decapeptyl ® Depot 3.75 mg formulated using the Debio ® PLGA proprietary
technology is a controlled release 1-month intramuscular injectable formulation of
triptorelin pamoate, an LHRH or GnRH agonist
Decapeptyl ®
(Debiopharm)
Triptorelin
Nutropin Depot ®
(Genentech-
Alkermes)
GH
Recombinant
hGH
Somatropin (rDNA origin) for injectable suspension, sterile lyophilized PLGA
microspheres, available in 13.5, 18, and 22.5 mg. Stimulates longitudinal bone
growth and elevates IGF-I levels
Sandostatin ® LAR Depot incorporates octreotide acetate for injectable suspension
into microspheres of the biodegradable glucose star polymer, D,L-lactic, and
glycolic acids copolymer. Available in 10, 20, and 30 mg, given as a monthly
intragluteal injection in acromegalic patients and in malignant carcinoid syndrome
Sandostatin LAR ®
Depot (Novartis)
GH
suppression,
anticancer
Octreotide
acetate
Somatuline ® LA (Ipsen)
Acromegaly
Lanreotide
Lanreotide, 0.030 g. Each vial is filled with a quantity of microparticles of lanreotide
acetate and PLGA copolymers corresponding to 40 mg of lanreotide base, which
ensures the actual injection of 30 mg of lanreotide. Given once every 14 days in
acromegaly and thyrotrophic adenomas
Posilac ® (Monsanto)
Milk
production
enhancer in
cattle
Recombinant
bovine
somatotropin
POSILAC (sometribove zinc suspension) is a sterile, prolonged release injectable,
oil-based formulation of a recombinant DNA-derived bovine somatotropin
analogue in single-dose syringes each containing 500 mg of sometribove zinc
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