Parenteral Delivery of Peptides and Proteins - Challenges in Delivery of Therapeutic Genomics and Proteomics - page 551

Protein/Peptide Category Delivery System Along with Polymer Therapeutic

Application

Reference

Parathyroid hormone Hormones PLGA microspheres, improved release profile, and local delivery

to bone

Calcium regulator [175]

Insulin Hormones PLGA nanoparticles; improved loading, release profile, and

stability

Hypoglycaemic
hormone

[176]

Leuprolide Hormones Phase-sensitive formulations; prepared by dissolving D,L-PLA in a

mixture of organic solvents, benzyl benzoate (BB), and benzyl
alcohol (BA); controlled release rate

LHRH analogue [177]

Nafarelin Hormones PLGA microspheres, improved release rate LHRH analogue [178]

Orntide Hormones PLA and PLGA microspheres, improved controlled delivery up to

4 months

LHRH analogue [179]

Tetracosactide Hormones PLA and PLGA microparticles, prepared using supercritical fluid

technology

Corticotrope
hormone

[180]

Erythropoietin Cytokines PLGA microparticles, tested for stability using various excipients Red cell

proliferation and
differentiation
regulator

[102]

Insulin-like growth
factor-I

Cytokines PLGA microparticles, tested for stability using various excipients Osteogenesis

promotor

[98]

Interleukin Cytokines PLGA microparticles. Controlled delivery for tumor

immunotherapy

Cytokine,
antitumoral agent

[126]

Interferon Cytokines PLGA microparticles, tested for stability using various excipients Cytokine,

antitumoral agent

[108]

Tumor necrosis factor Cytokines PEGylated polycyanoacrylate nanoparticles, controlled release has

been achieved

Antitumoral agent [181]

Vascular endothelial
growth factor

Cytokines PLGA microspheres for effective local angiogenesis Cytokine [182]

Nerve growth factor Other

proteins

PLGA microspheres, stabilized using coencapsulation of PEG 400 Neurotrophic factor [100,183]