Biomedical Engineering Reference
In-Depth Information
Table 11.2 List of Reported P/P Entrapped in Particulate Carriers
Protein/Peptide
Category
Delivery System Along with Polymer
Therapeutic
Application
Reference
Diphtheria toxoid
Antigens
Poly-(-caprolactone) nanoparticles as mucosal vaccine delivery
systems
Vaccine
[167]
Escherichia coli
colonization factor
CS3
Antigens
PLGA microspheres, enhanced the immunogenicity of the CS3-
PLGA microspheres (increased level of serum and mucosal
antibodies) than native CS3
Vaccine
[168]
Hepatitis B core antigen
Antigens
PLGA microspheres, long-acting hepatitis B vaccine. Gelatin used
as a stabilizer
Vaccine
[85]
Staphylococcal
enterotoxin B-toxoid
Antigens
PLGA nanospheres. Reported as an effective adjuvant
Vaccine
[169]
Tetanus toxoid
Antigens
Chitosan microspheres; found successful in maintaining antibody
titre for a prolonged period
Vaccine
[170]
Asparaginase
Enzymes
PLGA nanospheres, stabilized by various additives. Improved
biological activity
Antitumoral agent
[80]
Chymotrypsin
Enzymes
PLGA microspheres, stabilized by various additives. Improved
biological activity
Proteolytic enzyme
[111]
Lysozyme
Enzymes
PLGA microspheres, improved release kinetic and stability of
lysozyme
Mucolytic agent,
antiviral agent
[89]
Protein C
Enzymes
Monomethoxypoly (ethylene oxide)-PLA nanoparticles improved
loading efficiency
Anticoagulant agent
[171]
Trypsin
Enzymes
A novel heparin/protamine-based approach for delivery of enzyme
drugs without associated toxic effects has been proposed
Proteolytic enzyme
[172]
Calcitonine
Hormones
In situ biodegradable implant; PLA polymer; studied for effect of
cosolvent on release profile
Calcium regulator
[173]
Growth hormone
Hormones
Pluronic copolymer hydrogel. Pluronic copolymer end-capped
with D- or L-lactic acid oligomers (PL-LA n ), evaluated for
release kinetics
GH
[174]
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