Biomedical Engineering Reference
In-Depth Information
Bioadhesive Materials
Properties
Characteristics
l Solutions show fair to good tolerance of water-
miscible solvents (10-30% of volatile solvents;
40-70% of glycols).
l Compatible with most water-soluble thickeners and
resins
l Solutions more resistant to bacterial and enzymatic
degradation than many other organic thickeners
Poly (hydroxy butyrate), Poly
(e-caprolactone) and copolymers
l Biodegradable
l Properties can be changed by chemical
modification, copolymerization, and blending.
l Used as a matrix for drug delivery systems, cell
microencapsulation
Poly (ortho esters)
l Surface eroding polymers
l Application in sustained drug delivery and
ophthalmology
Poly (cyano acrylates)
l Biodegradable depending on the length of the
alkyl chain
l Used as surgical adhesives and glues
l Potentially used in drug delivery
Polyphosphazenes
l Can be tailored with versatile side chain
functionality
l Can be made into films and hydrogels
l Applications in drug delivery
Poly (vinyl alcohol)
l Biocompatible
l Gels and blended membranes are used in drug
delivery and cell immobilization.
Poly (ethylene oxide)
l Highly biocompatible
l Its derivatives and copolymers are used in various
biomedical applications.
Poly (hydroxytheyl methacrylate) l Biocompatible
l Hydrogels have been used as soft contact lenses,
for drug delivery, as skin coatings, and for
immunoisolation membranes.
Poly (ethylene oxide- b -propylene
oxide)
l Surfactants with amphiphilic properties
l Used in protein delivery and skin treatments
Ref. [160] . (Reprinted with permission from Elsevier)
 
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