Biomedical Engineering Reference
In-Depth Information
Bioadhesive Materials
Properties
Characteristics
l
Solutions show fair to good tolerance of water-
miscible solvents (10-30% of volatile solvents;
40-70% of glycols).
l
Compatible with most water-soluble thickeners and
resins
l
Solutions more resistant to bacterial and enzymatic
degradation than many other organic thickeners
Poly (hydroxy butyrate), Poly
(e-caprolactone) and copolymers
l
Biodegradable
l
Properties can be changed by chemical
modification, copolymerization, and blending.
l
Used as a matrix for drug delivery systems, cell
microencapsulation
Poly (ortho esters)
l
Surface eroding polymers
l
Application in sustained drug delivery and
ophthalmology
Poly (cyano acrylates)
l
Biodegradable depending on the length of the
alkyl chain
l
Used as surgical adhesives and glues
l
Potentially used in drug delivery
Polyphosphazenes
l
Can be tailored with versatile side chain
functionality
l
Can be made into films and hydrogels
l
Applications in drug delivery
Poly (vinyl alcohol)
l
Biocompatible
l
Gels and blended membranes are used in drug
delivery and cell immobilization.
Poly (ethylene oxide)
l
Highly biocompatible
l
Its derivatives and copolymers are used in various
biomedical applications.
Poly (hydroxytheyl methacrylate)
l
Biocompatible
l
Hydrogels have been used as soft contact lenses,
for drug delivery, as skin coatings, and for
immunoisolation membranes.
Poly (ethylene oxide-
b
-propylene
oxide)
l
Surfactants with amphiphilic properties
l
Used in protein delivery and skin treatments
Ref.
[160]
. (Reprinted with permission from Elsevier)
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