Biomedical Engineering Reference
In-Depth Information
Table 7.7
Patent Scenario in the USA for Major Companies Involved in siRNA Therapeutics
S. No.
Company
Trend of Patents/
Applications
Approximate Number
of Granted Patents
Approximate
Number of
Applications
1.
Sirna Therapeutics
A. Targeted delivery of nucleic acids using lipid nanoparticle-based
compositions and various ligands
B. Conjugates and chemically modified compositions for cellular
delivery of negatively charged molecules
C. Synthesis, deprotection, analysis, and purification of RNA and
ribozymes
D. siRNA-based treatment of diseases
25
202
2.
Dharmacon
A. Effective designing of siRNA to synthesize modified and stabilized
polynucleotides for use in RNAi for gene-specific targeting
B. Functional and hyperfunctional siRNA
C. Methods and compositions for selecting siRNA of improved func-
tionality
35
141
3.
Alnylam
A. RNAi modulation of ApoB, RSV, MLL-AF4, PIV, etc., and method
of treating neurodegenerative diseases
B. Chemically modified
oligonucleotides
C. Glycoconjugates and cationic lipid derivatives of siRNA
D. Compositions and methods for inhibiting expression of various
respiratory virus genes
17
26
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