Biomedical Engineering Reference
In-Depth Information
(A)
Acetylcholine
Closed K + channel
G protein-linked
receptor
GTP
Activated β - γ complex
Plasma membrane
Open K + channel
Inactivation by
phosphate loss
GTP
Closed K + channel
GTP
Inactive G protein
(B)
Signal
Activated α
subunit
G protein-linked
receptor
GTP
Activated adenylyl cyclase
ATP
Cyclic AMP
Inactive PKA
Active PKA
Nucleus
Nuclear pore
Activated gene regulatory protein
Activated target gene
DNA
Figure 1.9 Signal transduction via G protein-coupled receptor.
 
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