Biomedical Engineering Reference
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(A)
Acetylcholine
Closed K
+
channel
G protein-linked
receptor
GTP
Activated
β
-
γ
complex
Plasma membrane
Open K
+
channel
Inactivation by
phosphate loss
GTP
Closed K
+
channel
GTP
Inactive G protein
(B)
Signal
Activated
α
subunit
G protein-linked
receptor
GTP
Activated adenylyl cyclase
ATP
Cyclic AMP
Inactive PKA
Active PKA
Nucleus
Nuclear pore
Activated gene regulatory protein
Activated target gene
DNA
Figure 1.9
Signal transduction via G protein-coupled receptor.
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