Biomedical Engineering Reference
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protein into
short peptides
MHC I
T-cell receptor
Peptides
Cytosolic
antigen
DNA vaccine
Cytokines
for CD8+
MHC class I
glycoprotein
Exogenous antigen
Golgi
apparatus
Acidified
endosome
mRNA
Endocytosis
MHC II
DNA
Transmembrane or
secreted antigen
CD4
T-cell
receptor
CD4 + T-cell
(Th)
MHC class II
glycoprotein
Antibody
Cytokines
for antibodies-
mediated response
B-cell
Figure 6.4
Mechanisms of DNA vaccine-induced humoral and cellular immune responses. (A) Recognition of exogenous antigen by APC and
activation of a humoral immune response. (B) T-helper cell activation by antigen presentation via MHC II molecules of the transfected APC.
(C) Activation of CTL by the presentation of foreign peptides synthesized and processed by the transfected cell via MHC I molecules.
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