Gene Delivery Using Viral Vectors - Challenges in Delivery of Therapeutic Genomics and Proteomics - page 212

Adenovirus

Penton base
Fiber
Knob

Receptor 1
CAR protein
virus attachment

Cell

Figure 5.4 Adsorption and entry into the cell.

Figure 5.5 Binding and
internalization of adenovirus.

Receptor 2 “ α ν integrins”-mediated virus internalization

and provide functions that promote virus DNA replication and shut-off of host protein
synthesis. Furthermore, E4 products prevent viral DNA concatenation (head-to-tail
array of covalently joined DNA sequences generated by concatenation). Concatenated
DNA is attached end to end in contrast to catenated DNA, which is attached loop